Europe faces ‘recession of historic proportions’

European Commissioner for Economy Paolo Gentiloni | Gali Tibbon/AFP via Getty Images

Europe faces ‘recession of historic proportions’

Economy, employment dive in pandemic fallout.

By

5/6/20, 11:13 AM CET

Updated 5/6/20, 2:36 PM CET

The eurozone economy is set to shrink by 7.75 percent this year due to the coronavirus, a contraction overshadowing the worst of the financial crisis in 2009.

The European Commission called it a “recession of historic proportions” today in its spring forecast, which also warned EU unemployment could climb to 9 percent this year.

Things could get still worse depending on how the pandemic evolves, the Brussels executive said. The financial crisis contracted the eurozone economy by 4.5 percent in 2009 and left around 10 percent of workers without a job.

The euro-area economy should bounce back next year with gross domestic product growing by 6.25 percent, the Commission added. But the recovery will differ across the single currency union.

“The depth of the recession and the strength of recovery will be uneven, conditioned by the speed at which lockdowns can be lifted, the importance of services like tourism in each economy and by each country’s financial resources,” the Commission’s economy chief, Paolo Gentiloni, said in a statement.

“Such divergence poses a threat to the single market and the euro area,” he continued — a divergence that would exasperate a north-south divide in the EU that began after crises in the financial system and government debts.

“Yet it can be mitigated through decisive, joint European action,” the Italian said. “We must rise to this challenge.”

Gentiloni’s rallying call comes as President Ursula von der Leyen scrambles to propose to leaders a trillion-euro recovery fund that can revive the bloc’s economy.

Authors:
Bjarke Smith-Meyer 

Poland’s Schrödinger’s election

WARSAW — Is it an election if no one votes?

That’s the Zen riddle that Poland will be grappling with over the weekend thanks to a presidential election scheduled for Sunday that isn’t being called off but also won’t happen.

Jarosław Kaczyński, the leader of the ruling Law and Justice (PiS) party and Poland’s de facto ruler, issued a statement late Wednesday saying that the May 10 vote will be annulled once the Supreme Court certifies that the election didn’t happen, and that the speaker of parliament will then set a new date for a postal-only vote.

It’s a relief to opposition candidates who feared being trounced by incumbent Andrzej Duda, and to the European Commission and international organizations, which had become increasingly alarmed at the headlong rush to hold a vote on Sunday despite the coronavirus pandemic.

But that doesn’t mean the electoral clock is stopped. Poland’s National Electoral Commission website is still counting down the hours until the vote begins.

It’s just that on Sunday morning, no polling stations will be open.

The bizarre situation is a defeat for Kaczyński, who had pushed so hard for the Sunday election that it split the country and threatened to break apart his right-wing ruling coalition. But that effort ran into so many logistical, political and legal hurdles that even the stubborn PiS leader had to give way when faced with the threat of losing his parliamentary majority.

The election was scheduled months ago, but then the coronavirus hit — turning the normal procedure of voting into a potential killer.

There is a legal way of delaying a vote: The government could declare a state of natural catastrophe, which automatically shifts elections until 90 days after such a state is lifted. However, Law and Justice refused to take that step — in large measure because Duda is far ahead in opinion polls.

Switching to an election months from now could provide an opening for the opposition. There’s also the danger of a worsening economic and health toll from the pandemic, which so far has been less deadly in Poland than in many Western European countries, killing 755 and infecting 15,047.

Political contortions

Kaczyński’s ploy left the rest of the country scrambling to figure out the new political and legal landscape.

Joanna Lemańska, head of one of the divisions of the Supreme Court, was nonplussed by Kaczyński — legally nothing more than a run-of-the-mill MP — dictating a verdict for what’s supposed to be an independent legal body.

“I was very surprised about the information that a decision has been taken about the [court’s] future ruling,” she told the Onet news portal.

Opposition candidates — who had conducted a debate with Duda on national television just before Kaczyński dropped his announcement — attacked the move, although there’s broad satisfaction that a vote they were very likely to lose has been delayed.

Robert Biedroń, the candidate of the left, called the way the decision was made a “coup d’état” and said that those responsible should face legal sanctions.

For more polling data from across Europe visit POLITICO Poll of Polls.

“Kaczyński stole Poland from us,” said Szymon Hołownia, a fast-rising independent candidate.

Duda said he was “very satisfied” with the decision to delay the vote.

It’s still unclear when a new vote will be held — with dates from June to August being suggested. The parliament on Thursday passed a law changing the format of the election to only allow mail-in ballots. Parliament is due to pass a new electoral law next week reinstating the electoral commission as the body running the election; it had been sidelined as Kaczyński attempted to ram through a May 10 vote.

It’s also unclear whether the existing candidates, each of whom had to gather 100,000 signatures to take part, will be automatically included in the new election, and whether new candidates will be able to run.

That opens a possible window of opportunity for Civic Platform, the largest opposition party. It could potentially shift candidates as its current nominee, Małgorzata Kidawa-Błońska, is doing badly in opinion polls, although she did say it was an opposition success to halt the “insanity” of holding an election on Sunday.

The clock reset is also being greeted with relief in Brussels.

The European Commission was careful to stress that arranging elections is something that’s under the control of national authorities, but added that such a vote should be consistent with “European standards” that include “sound electoral processes, legal certainty refraining from short-term changes to electoral laws, free and secret suffrage and a fair electoral campaign.”

Katarina Barley, vice president of the European Parliament and a former German justice minister, was more cutting. She called the decision to delay the election “overdue,” but added, “It would be a mistake to think the PiS government’s undermining of democracy and the rule of law stops here … A route towards free and fair elections is still not visible.”

Ajax explain why they will sell Man United, Chelsea targets

Ajax have confirmed that Manchester United target Donny van de Beek is one of three players they will make available this summer.

Manchester United have been monitoring developments with regards to Van de Beek’s future throughout the season.

Real Madrid were thought to be favourites to sign the midfielder but may no longer be in a position to afford him, making Manchester United primary contenders.

Ajax chief executive Edwin van der Sar has, however, warned the likes of his former club that “there won’t be a 50 per cent discount” on any players due to the global pandemic.

But Van de Beek, along with Chelsea goalkeeper target Andre Onana and left-back Nicolas Tagliafico, will be made available after the club promised to reassess their stance if they stayed for one more campaign last summer.

“Last year, we made verbal agreements with Onana, Tagliafico and Van de Beek to stay another season, and then we look to help each other and find the next step in their careers. Nothing has changed,” Van der Sar told Reuters.

“There won’t be a 50 per cent discount. The clubs can forget about that.

“In January last year, people said we were going to lose seven or eight players but we lost only two key members.

“The big clubs such as Bayern Munich have said the benchmark fee will go down in the next few transfer windows. But it’s easier for them to say because they are the buyers.

“Of course, the 150m-200m euros transfers are gone. But I think there is still a lot of value for players who come from Ajax: Well educated, experienced in winning and playing European football.”

We could not keep away from the camera for long so we made a Football365 Isolation Show. Watch it, subscribe and share until we get back in the studio/pub and produce something a little slicker…

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Robertson picks out surprising regret from Barcelona demolition

Liverpool defender Andy Robertson has surprisingly admitted that he regrets ruffling Lionel Messi’s hair during their epic 4-0 victory over Barcelona in the Champions League last season.

Barcelona looked set to make the Champions League final after securing a 3-0 lead after the semi-final, first leg at the Camp Nou, but a trademark Anfield European night saw their dreams turn to nightmares after the Reds roared back to advance with a 4-3 aggregate victory.

It was arguably Anfield’s greatest ever European night with two goals apiece from Divock Origi and game-changing half-time substitute Georginio Wijnaldum seeing them progress 4-3 on aggregate, almost a year to the day.


FEATURE: The most expensive transfer from FIFA’s top 25 countries


Robertson put in a huge performance on the night, and only now has he finally admitted to regretting his actions.

Robertson decided to press down hard on Lionel Messi’s head, an action which the Scot know thinks was an error, but at the time it seemed to take the Anfield atmosphere up a notch, and probably aided their comeback.

“Me and Fabinho were both tracking him (Messi) back, and we both ended up on the ground, and… yeah I just ruffled his hair a wee bit,” Robertson said on That Peter Crouch Podcast.

“He wasn’t too happy, but it’s something I wouldn’t do again that’s for sure! It’s a bit disrespectful to the best player that’s ever played this game.

“He was on the ground and I was on the ground, and I do regret it. But it’s something that everyone relates to me now, which isn’t the best!”

It was the second successive season that Barca had lost a commanding lead in Europe, and Messi revealed that the squad were still recovering ahead of the Copa del Rey final later that month, which they lost 2-1 to Valencia.

He said: “The Liverpool game was a really hard blow for us.

“Not just for me, but for the whole squad, and it has been hard to recover from it.

“We were terrible on the night at Anfield and to lose in the same way twice in two years is not acceptable.”

 

We could not keep away from the camera for long so we made a Football365 Isolation Show. Watch it, subscribe and share until we get back in the studio/pub and produce something a little slicker…

The Menace Of Bullies: Patch's Experts Answer Your Questions

As part of Patch’s year-long reporting project on bullying and cyberbullying, we’ve assembled a panel of experts to offer helpful advice on navigating what for many is a tortured path through their adolescence and teen years. These nationally recognized experts and educators will answer readers’ questions during October, National Bullying Prevention Month, and throughout the remainder of the year.

Bruises and torn clothing make it easy for parents to see if their child has been physically bullied, but other effects of torment are more easily hidden. Some kids weather it, but for others, bullying and cyberbullying may have life-altering consequences.

Below, meet Patch’s experts and read their answers to some of the questions that frequently surfaced in comments and emails in response to our Patch series, “The Menace Of Bullies.” To submit a question, we’ve embedded an easy-to-use form at the bottom of this story, or you can email your question to [email protected].

The Patch Experts

Jim Dillon has been an educator for more than 35 years, including 20 years as a school administrator. While a principal at an elementary school in New York, he developed the Peaceful School Bus Program to prevent and reduce bullying and it is now being implemented at schools around the country. A certified bullying prevention program trainer, he’s a coach for the Center for Leadership and Bullying Prevention and was a participant and presenter at the first National Summit on Bullying Prevention.

Ross Ellis, founder and CEO of STOMP Out Bullying, is nationally recognized for her work in preventing bullying, cyberbullying and violence against children, and also is an online safety expert. Her organization’s services include a help/chat line that is staffed round the clock. She provides expert commentary for news stories about bullying and cyberbullying, and also is a frequent keynote speaker on the topics.

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Suzanne Principe taught for 31 years before she retired in 2010, and comes from a family of teachers and school administrators. She spent the bulk of her career in New Haven, Connecticut, where she taught mostly kindergarten, but also fourth grade and second grade. She says she’s not surprised at the increase in bullying, given the violence youths see on television and in adult behavior. She believes in “personal responsibility” and says that “people are in charge of their own behavior and teaching children the same way.”

Dr. Steven Richfield is a clinical psychologist with more than 30 years experience. He maintains a full-time private practice in a Philadelphia suburb, has written about bullying for Patch and in 1998, published his “Parent Coaching Cards” that have been used worldwide to help parents develop skills that will address the source of their kids’ social and behavioral struggles.

Nancy Willard, who has a master’s degree in special education and is an attorney, is the founder and director of Embrace Civility in the Digital Age. A pioneer in cyberbullying research and a published author on bullying prevention, she believes that parents and other adults in a position of authority, including school officials, need to teach civility both through leadership and more directly in civility education.

You Asked …

How can I tell if my child is being bullied?

Many adolescents and teenagers may be reluctant to admit they’re being bullied or feel stigmatized by it, but they’re also at an age where they are exerting their independence from their parents and feel they can handle things on their own, Dillon says, so asking them about bullying directly may be counterproductive.

Dillon advises: “It is important to make sure that you have regular conversation times with your child so that they become accustomed to talking in general about how things are going in their lives. Given all that, I would be alert for changes in their mood, any hesitancy they might have to go to school, and/or any reluctance to participate in social events. These non-verbal cues might be red flags. It is also helpful to have relationships with your child’s friends who could tell you how things are going in school. A sibling might also be able to share some information about what is happening in school.”

Ellis says bullying can take several forms: physical (hitting, punching, beating); verbal (teasing, name calling, threats); emotional (intimidation using gestures, social exclusion, threats); sexual; racist bullying, cyberbullying (online harassment, hate messages, threats, impersonation and other digital abuse); or hazing.

Some warning signs to look for:

Ellis says children with disabilities may be at higher risk of being bullied than other children, and that the symptoms of bullying could also indicate other types of abuse. If your child displays any of those signs, talk with them and the school staff to learn more about what’s going on, she says.

What can I do to make sure my child has positive relationships with her peers? Are there social skills I can actively coach to reduce the chance he will be targeted by kids who bully?

First, Richfield says, it’s important for parents to build an open and trusting relationship with their children to increase the chances they’ll talk about their encounters with their peers, either good or bad. It’s also important that they believe the information will be kept private and won’t be shared with other adults, except the other parent.

“Many children in my practice have shared their fear that a mother/father will speak to parents of their friends about the substance of what they share, and that this will ‘backfire big time’ on them,” Richfield says. “Don’t minimize the significance of what they share, as your child may then associate your response to one incident as indicative of how you will respond to others. Consider that sometimes they may be ‘testing’ you to determine your trustworthiness.

“The issue of whether kids can trust that their parents will not over-react, minimize, or share with other ancillary adults, is often the determiner of whether parents hear about the more significant events in their peer life.”

Without excusing kids who bully, gently suggest to your child that he may be drawing negative attention to themselves through things like poor hygiene, clothing that is too immature for their age, attention-seeking or regressive behaviors, and self-control.

“If your child displays any of these red flags, offer to help them upgrade,” Richfield says. “Confident communication skills is one of the keys to helping your child build positive relationships with peers.”

If I suspect my child is being bullied, but won’t open up, what are some ways I can start the conversation?

As Richfield noted, it’s important for parents to gently question their children without being intrusive and to make it “safe” for them to open up, Willard says. They may think they deserve the treatment or feel shame about failing to effectively respond to bullying, or that their parents will notify school officials, who may not respond in a way that is helpful and, published research suggests, make things worse.

“So what is the answer? Improving the response,” Willard says. “I think the bottom-line concern of any young person is that if he or she tells any adult what is happening, the adult will want to take things over and try to ‘fix things’ — which has a good chance of making things worse.

“What young people want most is autonomy — personal control. Especially if they are being bullied, their personal power is being taken away. They don’t want some adults doing more to take away their personal power. So an absolute solid commitment needs to be made to any child or teen who is being bullied: Nothing will happen in an effort to address this situation without their full participation and approval!

“Parents can lay the groundwork for this by always avoiding efforts to control their child and instead shift to engaging with their child in problem solving to decide how to proceed.”

What should I do if I think my child is a bully?

The tendency to bully can begin before school age if children are reared in an environment without structure and discipline, says Principe, who cites federal research that suggests if children haven’t learned self-discipline and self-control by age 7, they’re less likely to later on.

“If you think your child is a bully, he probably is,” Principe advises. “Check your structure at home first — rules and boundaries. If you have none, start slow and be firm. Make sure you know where your child is at all times and what they are doing, and how they talk to others on the phone or in person.

“Model correct behavior,” she continues. “It won’t be easy and won’t happen quickly, but the more modeling you do — the nicer you are to other people you encounter in life with your child — the better and better they become.

“Talk with them and share stories of your encounters in your young life of any times you encountered bullying and how you handled it. Tell them if you were a bully and how much you regret it now.

“Teachers often have good suggestions so speak to your child’s teacher. If you have heard from the teacher that your child bullies others, please support the teacher. Don’t scream at the teacher and expect her to instantly change your child’s behavior. It started a long time ago at home.”

Do you have a question for our experts? Pose it in the form below:

The Menace Of Bullies: A Patch Series

Through the end of the 2018, Patch will continue its in-depth look at society’s roles and responsibilities in bullying, which can lead to a child’s unthinkable decision to end their own life, in hopes we might offer solutions that save lives.

Do you have a story to tell? Are you concerned about how your local schools handle bullies and their victims?

Email us at [email protected] and share your views in the comments.

Earlier In This Series

Patch graphics by Kristin Borden

Sex Crime Charge Against Harvey Weinstein Tossed By Judge

NEW YORK — A Manhattan judge tossed a sexual assault charge against Harvey Weinstein on Thursday after evidence raised questions about one accuser’s account. Without opposition from prosecutors, the judge dismissed one criminal sexual act charge against Weinstein accusing him of forcing a woman to perform oral sex, the Manhattan District Attorney’s Office said.

Prosecutors admitted to Weinstein’s lawyer last month that a friend of the woman he was accused of violating — reportedly the onetime aspiring actress Lucia Evans — gave an account of the 2004 incident that was “at odds” with the woman’s.

But that doesn’t weaken the case against Weinstein overall, Assistant District Attorney Joan Illuzzi said. The disgraced movie mogul still charged with five crimes, including rape and predatory sexual assault.

“We are moving full steam ahead,” Illuzzi said during a Thursday morning court hearing, according to the Manhattan DA’s office. “As we do with every case, we will follow the facts of law wherever they may lead, and protect those who are preyed upon as well as the integrity of the process.”

Weinstein was accused in July of assaulting and raping three women in an indictment that spanned nine years. He was first arrested in May on charges involving two of the women.

Evans was among three women who accused Weinstein of rape in an October 2017 New Yorker article that detailed his pattern of abusive conduct with women. She reportedly alleged that Weinstein forced her to perform oral sex on him at his Tribeca office in 2004.

A woman who was with Evans that night said Evans later told her that she performed the act after Weinstein promised to get her an acting job in exchange for oral sex, according to a Sept. 12 letter from the DA’s office to Weinstein’s attorney, Benjamin Brafman.

Prosecutors also got ahold of a draft email Evans wrote in 2015 that differs from the account she gave the DA’s office, according to the letter.

But Evans told the DA’s office she never consented to any sex with Weinstein and does not remember describing the 2004 incident to the other woman, the letter says.

Carrie Goldberg, a lawyer for Evans, reportedly said the DA’s decision to “abandon” her was disappointing.

“Let me be clear: the decision to throw away my client’s sexual assault charges says nothing about Weinstein’s guilt or innocence,” Goldberg said in a statement to the Associated Press. “Nor does it reflect on Lucia’s consistent allegation that she was sexually assaulted with force by Harvey Weinstein.”

Weinstein has denied all allegations of nonconsensual sex. Brafman reportedly suggested Evans should be charged with perjury.

“The integrity of these proceedings has been compromised,” Brafman said, according to the AP.

Weinstein is next due in court on Dec. 20, the DA’s office said.

The New Yorker’s and The New York Times’ investigations of Weinstein’s long history of sexual misconduct sparked a reckoning with sexual assault and abuse of power that became the worldwide #MeToo movement. The two publications won a Pulitzer Prize for their work earlier this year.

(Lead image: Harvey Weinstein appears in Manhattan Criminal Court on Thursday. Photo by Stephanie Keith/Getty Images)

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Purple Heart Recipient Armed With Gift Of Sight

SAN JOSE, CA — When Leonard Vigil, 37, lost consciousness from a roadside bomb while serving in Ramadi, Iraq, for the U.S. Marines from 2001-05, he didn’t realize he would lose much of his vision too.

“I was completely out. (When I came to), there was a lot of smoke and everything was blurry,” the San Jose resident said. The moment during a four-year deployment with the Corps changed his life physically and emotionally. He only had one year left in his term — but it didn’t end soon enough to escape sustaining a traumatic brain injury that dramatically affected his vision. He also mentally dealt with losing 32 soldiers in his battalion. Vigil went to the Veterans Hospital in Palo Alto, worked with a speech therapist and saw a neurologist. All the while, his pull-yourself-up-by-your-bootstraps attitude motivated him to be a good husband and father, work in sales, coach high school wrestling and enroll in Pacific Oaks College’s master’s program in San Jose — despite grappling with “why I wasn’t learning” at the pace he wanted to.

“(My vision) wasn’t as clear as before. Everything was blurrier,” he said. He had 20/200 vision.

“It was hard to adjust,” he said, looking back at the challenging time. Vigil added feeling a sense of isolation being away from his buddies as exacerbating his problems. After all, this was a man who jumped up and tended to his buddies after the bomb blast despite his own injuries. The heroic gesture awarded him the prestigious Purple Heart, a military decoration for those wounded or killed while serving.

This is a man who puts others first. Now as the nation nears Veterans Day next month, a generous foundation and willing eye surgeon put him first this time. A few months ago, the Cost of Courage Foundation identified Vigil to receive the “gift of sight” in Dr. Michael Furlong’s program designed to pick up the tab for those needing eye surgery. Vigil had the surgery done about a week ago, and his vision is now 20/15.

“It is very rewarding for all recipients because we know how impactful (the surgery) can be to change their life,” said Furlong, the ophthalmologist who performed the pro-bono surgery on Vigil.

The lasik surgery only took about 15 minutes. But its impact is expected to last a lifetime.

“I’m just surprised other (medical) providers don’t do it. We went into this field for a reason. It only takes my time and expertise. And for me, it’s worth it,” said Furlong, who met the foundation founder Kelly Estes at a San Jose Earthquakes soccer match. Estes set up a booth for The Cost of Courage Foundation, a four-year-old nonprofit that supports the educational and personal needs of deserving military veterans in the community to ensure a successful transition back into civilian life.

She started her quest to help veterans in 2012 after her great uncle was killed in action. She wrote a book of the same name, and it became a launching pad to the foundation. Indeed, Estes can relate to Vigil’s drive. At age 19, she began serving on Santa Clara County’s Human Relations Commission, a 2009 to 2013 tour of duty that sought to reduce crime in the county brought on by post traumatic stress disorder.

“This taught me a lot. When people return from war, they’re not necessarily safe,” she said.

Her foundation has provided eye surgery for 24 veterans.

“It’s veterans like Leonard you just wanna help,” Estes said.

For more information, visit: https://furlongvision.com/inside-furlong-vision/gift-of-sight/ and www.thecostofcouragefoundation.org.

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See also https://patch.com/california/.

–Images courtesy of Jasmine and Leonard Vigil

Bientôt des images chocs sur les paquets de cigarettes !

L’arrêté portant sur la mise en place d’avertissements sanitaires graphiques sur les produits du tabac a été signé hier soir par la ministre de la santé Roselyne Bachelot. Une décision immédiatement saluée par l’Alliance pour le tabac, qui milite pour cette mesure depuis des années.

Des images comme celles ci-dessus, symboles des dégradations possibles de la santé en cas de

tabagisme chronique actif ou passif, devraient faire leur apparition dans les prochains mois (au plus tard dans 1 an) sur les paquets de cigarettes. Au grand dam des industriels des tabacs et des buralistes, “farouchement opposés à cette mesure“, selon l’Alliance contre le tabac.
Il faut dire qu’acheter un paquet recouvert de dents cariées, de tumeurs pulmonaire ou montrant une personne fumant par sa trachéotomie liée à un cancer pourrait décourager les fumeurs actifs et les jeunes qui souhaitent commencer à fumer, ce que ne veulent bien sûr surtout pas les fabricants de cigarettes. C’est en tout cas ce qui s’est produit dans les pays où cette mesure est entrée en œuvre depuis quelques années, comme par exemple le Canada, le Brésil ou encore la Thaïlande (voir notre article : “

Des avertissements chocs sur les paquets“)

L’Alliance espère donc que la signature de cet arrêté entrera rapidement en application, malgré les probables manoeuvres à venir du “lobby pro-tabac, visant à affaiblir la bonne application de cette mesure de santé publique“. Madame Bachelot a précisé qu’il y auara 14 types d’images chocs qui couvriront 40 % du recto du paquet, comme sur la maquette ci-contre.
Plus largement, cette signature est un signal positif de réengagement fort de l’Etat dans la lutte contre le tabagisme, alors qu’en 2009, les ventes de traitements antitabac ont baissé et celles de cigarettes sont reparties à la hausse…
Jean-Philippe Rivière
Sources :
– “Bachelot : « J’ai signé l’arrêté sur les images chocs »“, RMC (Jean-Jacques Bourdin), 16 avril 2010,

résumé écrit accessible en ligne sur le site de RMC
– “Avertissements sanitaires graphiques : L’Alliance contre le tabac salue la détermination de Roselyne Bachelot et la soutient contre la pression des industriels et des buralistes“, communiqué de presse, 16 avril 2010
Photo : Paquets de cigarettes Thaïlandais avec images dissuasives. © SALOM-GOMIS SEBASTIEN/SIPAClick Here: Maori All Blacks Store

Diminuer les effets secondaires du traitement de Parkinson

Les traitements de la maladie de Parkinson entraînent deseffets secondaires très gênants, notamment des mouvementsinvolontaires. Mais une équipe française vient de mettreà jour un mécanisme capable de réduire cesconséquences.

La maladie de Parkinson est une maladieneurodégénérative qui affecte le cerveau. Elle setraduit par de forts troubles moteurs (tremblements de repos,rigidité musculaire, ralentissement des mouvements…) dusà un manque de dopamine dans le cerveau. La thérapieà base de L-dopa comble ce manque et reste le meilleurtraitement connu à ce jour. Mais après quelquesannées, ce traitement peut entraîner des symptômestrès gênants, notamment des mouvementsinvolontaires (dyskinésies) et des fluctuations brutalesd’activité. L’un des enjeux de la recherche est donc dediminuer ces effets secondaires.
Une personne normale possède de la dopamine dans le cerveau,qui sert notamment au contrôle des fonctions motrices. Comptetenu de son importance, sa libération est très finementrégulée par des récepteurs à la dopamine,situés à la surface des neurones. Ainsi, lorsqu’il y atrop de dopamine ou qu’elle reste trop longtemps présente dansla synapse, les récepteurs se désensibilisent, stoppentleur réponse et disparaissent de la surface des neurones.Cette désensibilisation repose sur un mécanisme dit dephosphorylation, commandé par la protéine GRK6. Or chezles modèles animaux parkinsoniens dyskinétiques, lesrécepteurs à la dopamine restent continuellement àla surface des neurones, à cause d’un manque de GRK6.
Click Here: Maori All Blacks StoreLes chercheurs ont ainsi voulu corriger ce manque en stimulantl’expression de GRK6, injectant dans le cerveau cetteprotéine insérée dans un vecteurthérapeutique (un virus inoffensif). Résultat :cette action permet de retirer des récepteurs à ladopamine de la surface des neurones. Les animaux parkinsoniensdyskinétiques bénéficient du traitement à laL-dopa sans présenter de dyskinésiessévères.

Légende de l’illustration : Situation normale :la dopamine transmet le signal via ses récepteurs situésà la surface des neurones. Après stimulation par ladopamine, le récepteur est recyclé pour éviter unestimulation continue.Situation pathologique : La dopamine ne se lie plus àses récepteurs. Aucun signal n’est transmis. Lesrécepteurs séjournent à la surface du neurone. Ceciest la conséquence d’une diminution de ladisponibilité des protéines capables de les retirer de lamembrane (moins de GRK6)Les dyskinésies, survenant après un traitement deL-Dopa sur une longue période, pourraient êtrediminuées par la sur-expression de GRK6 dans le striatum.L’expression accrue des GRK6 (représentée parl’augmentation du nombre de cercles jaunes) permet alorsl’internalisation, à savoir le retrait de la surface desneurones, des récepteurs, et, par conséquent, ladiminution de la gravité des mouvements anormauxinvolontaires.Pour les chercheurs, “Cette avancée montre que nous nousintéressons à la bonne molécule. Mais nous sommesconscients que la technique que nous avons utilisée ne serapas rapidement accessible en routine chez l’homme. Nous avons doncd’autres idées pour proposer des solutions adaptées auxpatients parkinsoniens“ explique Erwan Bezard. Parmi lesstratégies envisagées, les chercheurs comptent passer aucrible toutes les petites molécules qui pourraient mimerl’action de GRK6.Luc BlanchotSources :– Communiqué commun Inserm-CNRS du 21 avril 2010- Sci Transl Med 21 April 2010: Vol. 2, Issue 28, p. 28ra28

(résumé accessible en ligne)Crédit illustration : les dessinateurs.com

Carnet rose : Claudia et Monica mamans à nouveau !

L’actrice Monica Bellucci, 45 ans, a donné naissance vendredi 21 mai à une petite fille du nom de Léonie. Heureux parents d’une petite Deva âgée de 5 ans, l’actrice italienne et Vincent Cassel viennent donc d’accueillir leur second petit trésor. La maman et sa fille se portent à merveille. D’après le site italien de

Vanity Fair, le bébé serait né à Rome et pèserait 3,2 kg pour 53 cm.

Peu de temps avant, le 14 mai, une autre jolie maman quadra, Claudia Schiffer (40 ans en août), a accouché d’une petite fille dont le nom n’a pas été communiqué. Elle vient rejoindre la tribu déjà composée de Caspar, 7 ans et Clémentine, 5 ans. C’est par un communiqué que la top et son mari, le réalisateur Matthew Vaughn ont annoncé la bonne nouvelle. Autre point commun, les deux jolies mamans avaient toutes deux

posé nues durant leur grossesse (Vogue allemand pour Claudia et Vanity Fair italien pour Monica). Félicitations aux deux mamans et plein de bonheur aux familles ! Emeline DufourPhoto : Vincent Cassel et Monica Bellucci à la cérémonie des Césars 2009. © NIVIERE/VILLARD/SIPA